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Contracts for Services to USA Nonprofits, For-Profits, Agencies,
and IHEs for Research Studies Related to High Blood Pressure

Health System Strategies to Address Disparities in Hypertension Management and Control

Agency Type:

Foundation / Corporation

Funding Source:

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Patient-Centered Outcomes Research Institute (PCORI)

Conf. Date:


LOI Date:


Deadline Date:

08/31/22 5:00 PM ET


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Contracts for services to USA nonprofit organizations, for-profit entities, government agencies, institutions of higher education, and health systems for research studies related to high blood pressure among underserved populations. Applications must submit an LOI prior to applying. Funding is intended for studies that address hypertension among vulnerable individuals.

PCORI seeks to fund rigorous, high-quality randomized controlled trials (RCTs) that compare health system strategies to improve blood pressure management and control in primary care, community, and safety net settings for populations experiencing disparities in outcomes, e.g., Black, Hispanic, rural, and/or uninsured individuals. This targeted funding announcement encourages multisite cluster RCTs with mixed methods design or robust process evaluation to support the possibility of widespread implementation. 

PCORI is particularly interested in RCTs in community, primary care, or safety net settings (i.e., providers that organize and deliver a significant level of health care to uninsured, Medicaid, and other vulnerable patients). Studies should conduct periodic outcome assessments, including long-term follow-up periods at or greater than 18 months. Studies should be powered to allow for conclusions regarding the populations of interest.

For information about specific program requirements, including interventions and outcomes, see:

GrantWatch ID#:

GrantWatch ID#: 203171

Estimated Total Program Funding:


Estimated Size of Grant:

Up to $15 million

Term of Contract:

Up to five years

Additional Eligibility Criteria:

Applications may be submitted by any private-sector research organization, including any nonprofit or for-profit organization; any public-sector research organization, including any university or college hospital or healthcare system; any laboratory or manufacturer; or any unit of local, state, or federal government. The Internal Revenue Service must recognize all U.S. applicant organizations. Organizations may submit multiple funding applications.

Nondomestic components of organizations based in the United States and foreign organizations may apply, as long as there is demonstrable benefit to the U.S. healthcare system and U.S. efforts in the area of patient-centered research can be shown clearly. However, PCORI’s general preference is that prime awards be made to a U.S.-based organization.

A prime award contract to a non-U.S.-based organization should be carefully justified and preferably include a key U.S.-based organization and co-Principal Investigator as a subcontractor.

Individuals are not permitted to apply.

For categories of unresponsiveness to the program requirements, see:

Pre-proposal Conference:

Pre-Application Information:

- Online System Opens: May 3, 2022
- Applicant Town Hall: May 19, 2022; 12:00 pm ET
- Letter of Intent Deadline: June 1, 2022; 5 pm ET
- LOI Status Notification: June 29, 2022
- Application Deadline: August 31, 2022, by 5 pm (ET)
- Merit Review: November 2022
- Awards Announced: March 2023
- Earliest Project Start Date: August 2023

Applying for funding for this PFA is a two-stage process. An LOI must be submitted, and an applicant must be invited to submit an application. Only applicants whose LOIs are deemed most responsive to this PFA will be invited to submit a full application.

To submit a Letter of Intent or application or to register your organization in PCORI Online, applicants must have an Employer Identification Number (EIN).

Applicant FAQ:

Program FAQ:

LOI Tips:

Contact Information:

Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.

Apply online:

Programmatic Inquiries:, or online (

Administrative, Financial, or Technical Inquiries:

Patient-Centered Outcomes Research Institute
1828 L St., NW, Suite 900
Washington, DC 20036
Phone: 202-827-7700
Fax: 202-355-9558

URL for Full Text (RFP):

Geographic Focus:

USA: Alabama;   Alaska;   Arizona;   Arkansas;   California;   Colorado;   Connecticut;   Delaware;   Florida;   Georgia;   Hawaii;   Idaho;   Illinois;   Indiana;   Iowa;   Kansas;   Kentucky;   Louisiana;   Maine;   Maryland;   Massachusetts;   Michigan;   Minnesota;   Mississippi;   Missouri;   Montana;   Nebraska;   Nevada;   New Hampshire;   New Jersey;   New Mexico;   New York City;   New York;   North Carolina;   North Dakota;   Ohio;   Oklahoma;   Oregon;   Pennsylvania;   Rhode Island;   South Carolina;   South Dakota;   Tennessee;   Texas;   Utah;   Vermont;   Virginia;   Washington, DC;   Washington;   West Virginia;   Wisconsin;   Wyoming

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