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Contracts for Services to USA For-Profits, Nonprofits, Agencies,
Labs, and IHEs for Research Related to Post-Pregnancy Problems

Improving Postpartum Maternal Outcomes for Populations Experiencing Disparities

Agency Type:

Foundation / Corporation

Funding Source:

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Patient-Centered Outcomes Research Institute (PCORI)

Conf. Date:


LOI Date:


Deadline Date:

08/31/22 5:00 PM


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Contracts for services to USA nonprofit organizations, for-profit entities, government agencies, institutions of higher education, and health systems for research studies and trials related to complications after pregnancy. Applicants must submit an LOI prior to applying. Funding is intended for large randomized controlled trials (RCTs) and observational studies comparing strategies to improve early detection of, and timely care for, complications up to six weeks postpartum for groups more often underserved or experiencing the greatest disparities in health outcomes, including Black, American Indian/Alaska Native (AI/AN), Hispanic, rural, and low socioeconomic status (SES) populations.

PCORI seeks to fund rigorous, high-quality, and impactful clinical studies that address the following research question: What is the comparative effectiveness of multicomponent interventions to improve early detection of, and timely care for, complications during the first six weeks postpartum and their risk factors for populations more often underserved and/or experiencing the greatest disparities in health outcomes, including Black, AI/AN, Hispanic, rural, and low SES patients?

For information about proposed interventions and outcomes, see:

Large randomized controlled trials (RCTs) are preferred; robust observational studies will also be considered if an RCT is not possible, and the proposed approach appropriately controls for confounding. Thoughtful use of new study designs, such as hybrid designs, could speed the translation of research findings into routine practice, identify more effective implementation strategies, and provide more useful information for stakeholders. For this PFA, one of the primary aims must be focused on a CER question, so hybrid type 1 and hybrid type 2 designs may be appropriate. Hybrid type 3 designs, for which the primary aim is implementation research, will not be considered responsive.

For information about general requirements and research priorities, see:

GrantWatch ID#:

GrantWatch ID#: 203170

Estimated Total Program Funding:


Estimated Size of Grant:

Up to $5 million (small studies) or $15 million (large studies)

Term of Contract:

- Up to five years
- Earliest Project Start Date: August 2023

Additional Eligibility Criteria:

Applications may be submitted by any private-sector research organization, including any nonprofit or for-profit organization; any public-sector research organization, including any university or college hospital or healthcare system; any laboratory or manufacturer; or any unit of local, state, or federal government. The Internal Revenue Service must recognize all U.S. applicant organizations. Organizations may submit multiple funding applications.

Nondomestic components of organizations based in the United States and foreign organizations may apply, as long as there is demonstrable benefit to the U.S. healthcare system and U.S. efforts in the area of patient-centered research can be shown clearly. However, PCORI’s general preference is that prime awards be made to a U.S.-based organization.

A prime award contract to a non-U.S.-based organization should be carefully justified and preferably include a key U.S.-based organization and co-Principal Investigator as a subcontractor.

Individuals are not permitted to apply.

Pre-proposal Conference:

Pre-Application Information:

- Online System Opens: May 3, 2022
- Applicant Town Hall: May 19, 2022; 12:00 pm ET
- Letter of Intent Deadline: June 1, 2022; 5 pm ET
- LOI Status Notification: June 29, 2022
- Application Deadline: August 31, 2022, by 5 pm (ET)
- Merit Review: November 2022
- Awards Announced: March 2023
- Earliest Project Start Date: August 2023

Applying for funding for this PFA is a two-stage process. An LOI must be submitted, and an applicant must be invited to submit an application. Only applicants whose LOIs are deemed most responsive to this PFA will be invited to submit a full application.

To submit a Letter of Intent or application or to register your organization in PCORI Online, applicants must have an Employer Identification Number (EIN).

Applicant FAQ:

Program FAQ:

LOI Tips:

Contact Information:

Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.

Apply online:

Programmatic Inquiries:, or online (

Administrative, Financial, or Technical Inquiries:

Patient-Centered Outcomes Research Institute
1828 L St., NW, Suite 900
Washington, DC 20036
Phone: 202-827-7700
Fax: 202-355-9558

URL for Full Text (RFP):

Geographic Focus:

USA: Alabama;   Alaska;   Arizona;   Arkansas;   California;   Colorado;   Connecticut;   Delaware;   Florida;   Georgia;   Hawaii;   Idaho;   Illinois;   Indiana;   Iowa;   Kansas;   Kentucky;   Louisiana;   Maine;   Maryland;   Massachusetts;   Michigan;   Minnesota;   Mississippi;   Missouri;   Montana;   Nebraska;   Nevada;   New Hampshire;   New Jersey;   New Mexico;   New York City;   New York;   North Carolina;   North Dakota;   Ohio;   Oklahoma;   Oregon;   Pennsylvania;   Rhode Island;   South Carolina;   South Dakota;   Tennessee;   Texas;   Utah;   Vermont;   Virginia;   Washington, DC;   Washington;   West Virginia;   Wisconsin;   Wyoming

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