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Cooperative Agreement to a USA Nonprofit, Agency, Hospital,
or IHE to Improve Outcomes for BIPOC HIV Patients

Increasing Uptake of Long-Acting Injectable Antiretrovirals Among People with HIV

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Funding Source:

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U.S. Department of Health and Human Services (DHHS) - Health Resources and Services Administration (HRSA)

Conf. Date:


Deadline Date:

06/21/22 11:59 PM ET


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Cooperative agreement to a USA nonprofit organization, government agency, IHE, tribe, nonprofit hospital, or outpatient clinic to improve treatment for BIPOC individuals diagnosed with HIV. Applicants are advised that required registrations may take as long as one month to complete. The successful applicant will provide technical assistance, capacity development, and evaluation to support ten demonstration sites in the development and pilot implementation of protocols for a novel long-acting injectable antiretroviral HIV treatment.

Increasing Uptake of Long-Acting Injectable Antiretrovirals Among People with HIV

The purpose of this program is to develop, implement, and evaluate protocols for successful use of long-acting injectable (LAI) antiretroviral (ARV) medication within clinical practice.

Increasing viral suppression and client retention in care are critical components of meeting the goals of the National HIV/AIDS Strategy (2022-2025) and ending the HIV epidemic. In order to reach these goals, it is imperative for HIV care communities to address health care inequities. With the advent of FDA-approved long-acting injectable (LAI) antiretroviral (ARV) medication formulations, initiatives that promote, facilitate, and evaluate the uptake and ongoing utilization of LAI ARV medication may improve clinical outcomes for people with HIV, especially for minority populations who continue to face disparate health care inequities and stigma. This project is designed to develop protocols, implement them and modify as needed, to increase uptake of LAI ARV medications among people of color with HIV, since LAI ARV medications may offer benefits in addressing health inequities and achieving viral suppression.

 In addition to alleviating challenges associated with oral medications, ongoing utilization of LAI ARV medications in lieu of oral regimens may potentially reduce HIV-related stigma and enhance protection of health privacy. While there are some unique clinical and social benefits to this injectable drug formulation, some aspects of its distribution, administration requirements, and billing have already hindered uptake and utilization within the Ryan White HIV/AIDS Program (RWHAP). As minority populations have historically experienced significant disparities in accessing care and treatment, including the health literacy and access to health care coverage options necessary to engage in care, developing interventions to increase the uptake of LAI ARV medication formulations will help to proactively address and potentially reduce or prevent disparities minority communities may face in accessing this breakthrough therapy.

This cooperative agreement will fund one (1) organization that will serve as the Coordination and Evaluation Provider (CEP) to support ten (10) demonstration sites in the development and pilot implementation of protocols for a novel LAI ARV HIV treatment. The CEP must have the capacity and infrastructure to support development, implementation, and refinement of LAI ARV medication administration protocols with the goal of replicating and expanding successful protocols. 

As of the release date of this NOFO, the current LAI ARV medication is now approved for injection every 2 months, requiring appointment attendance for injection at least 6 times per year versus the typical 4 or less annual visits for patients on daily oral regimens. The importance of increasing the uptake of this injectable is to eliminate the need for daily medication adherence and has significant implications for reducing stigma for patients currently taking oral HIV medications.

For program resources and models, see

For program involvement and expectations, and for recipient's responsibilities, see

GrantWatch ID#:

GrantWatch ID#: 202893

Estimated Total Program Funding:


Number of Grants:


Estimated Size of Grant:

Estimated Annual Award Amount:
- $1,500,000 in year 1 (FY 2022)
- $2,000,000 in year 2
- $2,000,000 in year 3
- $1,500,000 in year 4

Term of Contract:

Period of Performance: September 1, 2022 through August 31, 2026 (4 years)


  • City or township governments
  • County governments
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized tribal governments)
  • Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • See RFP and/or Grant Guidelines for full eligibility
  • Special district governments
  • State governments

Additional Eligibility Criteria:

Eligible applicants include entities eligible for funding under Parts A-D of Title XXVI of the Public Health Service (PHS) Act, including public and nonprofit private entities, state and local governments, academic institutions; local health departments; nonprofit hospitals and outpatient clinics; colleges and universities; community health centers receiving support under Section 330 of the PHS Act; faith-based and community-based organizations; and Indian Tribes or Tribal organizations with or without federal recognition.

For ineligible purposes and expenses, see:

Pre-proposal Conference:

HRSA has scheduled the following technical assistance:

Topic: Increasing Uptake of Long-Acting Injectable Antiretrovirals Among People with HIV NOFO TA Webinar
Time: Thursday, May 12, 2022 02:00 PM Eastern Time (US and Canada)

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Pre-Application Information:

The due date for applications under this NOFO is June 21, 2022 at 11:59 p.m. ET. HRSA suggests submitting applications to at least 3 calendar days before the deadline to allow for any unforeseen circumstances.

HRSA will release the Notice of Award (NOA) on or around the start date of September 1, 2022.

HRSA requires applicants to apply electronically through The registration process requires information in two separate systems:
- Dun and Bradstreet (
- System for Award Management (SAM)
- (

Ensure your and registrations and passwords are current immediately; HRSA will not approve deadline extensions for lack of registration. Registration in all systems may take up to 1 month to complete.

Multiple applications from an organization are not allowable. link:
For related documents, press the Package tab and click Preview on the page above.

Contact Information:

Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.

For information and/or technical assistance regarding business, administrative, or fiscal issues, please contact:
Beverly Helene Smith
Grants Management Specialist
Division of Grants Management Operations, OFAM
Health Resources and Services Administration
5600 Fishers Lane, Mailstop 10SWH03
Rockville, MD 20857
Telephone: (301)443-7065

For information regarding the overall program issues and/or technical assistance, contact:
Susan Robilotto, D.O., Director, Division of State HIV/AIDS Programs
Attn: Increasing Uptake of Long-Acting Injectable Antiretrovirals Among People
with HIV
Health Resources and Services Administration
5600 Fishers Lane, Room 09W52
Rockville, MD 20857
Telephone: (301) 443-6554

For technical assistance with submitting the application in, contact: Contact Center
Telephone: 1-800-518-4726 (International callers dial 606-545-5035)
Self-Service Knowledge Base

For assistance when working online to submit information and reports electronically, contact:
HRSA Contact Center
Telephone: (877) 464-4772 / (877) Go4-HRSA
TTY: (877) 897-9910

CFDA Number:


URL for Full Text (RFP):

Geographic Focus:

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