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Grants to USA, Canada, and International Investigators
for Research on Bloom Syndrome

Bloom Syndrome Grant Program

Agency Type:

Foundation / Corporation

Funding Source:

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University of Pennsylvania - Perelman School of Medicine - Orphan Disease Center (ODC)

LOI Date:

04/15/22

Deadline Date:

05/27/22 5:00 PM EST

Description:

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Grants to USA, Canada, and International investigators affiliated with nonprofit and for-profit organizations for research on Bloom Syndrome. Applicants are required to submit an LOI prior to a full grant application. Funding is intended for research pertaining to tumor biology and investigations that offer new therapies for individuals suffering from Bloom Syndrome.

The Orphan Disease Center (ODC) at the University of Pennsylvania is seeking grant applications that progress the discovery or development of treatments and/or cures for Bloom Syndrome. While the RFA is broad in scope, priority will be given to grants that cover the following areas:

  1. Improve knowledge of tumor biology, including, but not limited to tumor models, tumor sequencing and tumor signature for Bloom Syndrome, molecular surveillance for tumors, as well as a centralized registry of validated tissue (coordination of sampling, storing and distribution of samples).
  2. Novel therapeutic approaches for Bloom Syndrome, including, but not limited to, techniques in genome editing, RNA-based mechanisms, biologics, novel cell-based therapeutics, and development of novel therapeutic compounds, including through small molecule repurposing or screening against validated phenotypes in human cellular systems. 

Allowable direct costs:

  • Salary for PI
  • Salary/stipend and related benefits for graduate student/postdoctoral fellow/technical support
  • Travel (up to $1500)
  • Laboratory supplies and other research expenses

GrantWatch ID#:

GrantWatch ID#: 202307

Estimated Size of Grant:

Grants of $100,000 for two years and grants of $150,000 for two years.

Term of Contract:

Proposed funding period: July 1, 2022 – June 30, 2024

Additional Eligibility Criteria:

Non-profits: All individuals holding a faculty-level appointment at an academic institution or a senior position at a non-profit institution or foundation are eligible to respond to this RFA. Intellectual property created as a result of this funding will be assigned to the home institution of inventors according to standard institutional technology transfer policies. It is expected that these institutions will aggressively license these inventions to appropriate commercial entities with diligence provisions incorporated into these contracts.

Commercial entities: Applications will be accepted from commercial entities as long as a principal investigator of appropriate experience is identified. Intellectual property created as a result of this funding will be assigned to the home institution of inventors which presumably would be employees of the company.

Unallowable costs:
- Consultant costs
- Tuition
- Professional membership dues
- Equipment >$5,000
- General office supplies, institutional administrative charges (e.g., telephone, other electronic communication, IT network, etc.)
- Pre‐award charges
- Any other expenses not directly related to the project
- Indirect cost

Pre-Application Information:

Letter of Intent (LOI) are Due Friday, April 15, 2022 by 5 pm EST
Full Proposal Due Date: Friday, May 27, 2022, no later than 5 pm (EST).

It is expected that grants provided to commercial entities be matched dollar for dollar.

Additional Information: https://orphandiseasecenter.submittable.com/submit/db79fac9-91e7-4ec6-b713-58da1f187ca6/2022-bloom-syndrome-grant-program-loi

Contact Information:

Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.

Application: https://orphandiseasecenter.submittable.com/signup?returnUrl=%2fsubmit%2fdb79fac9-91e7-4ec6-b713-58da1f187ca6%2f2022-bloom-syndrome-grant-program-loi

For any scientific inquiries regarding this grant please email Debbie Requesens: dreques@upenn.edu

For any administrative inquiries regarding this grant please email Samantha Charleston: scharle@upenn.edu

University of Pennsylvania
TRL Suite 1200
125 South 31st Street
Philadelphia PA 19104

URL for Full Text (RFP):

Geographic Focus:

USA: Alabama;   Alaska;   Arizona;   Arkansas;   California;   Colorado;   Connecticut;   Delaware;   Florida;   Georgia;   Hawaii;   Idaho;   Illinois;   Indiana;   Iowa;   Kansas;   Kentucky;   Louisiana;   Maine;   Maryland;   Massachusetts;   Michigan;   Minnesota;   Mississippi;   Missouri;   Montana;   Nebraska;   Nevada;   New Hampshire;   New Jersey;   New Mexico;   New York City;   New York;   North Carolina;   North Dakota;   Ohio;   Oklahoma;   Oregon;   Pennsylvania;   Rhode Island;   South Carolina;   South Dakota;   Tennessee;   Texas;   Utah;   Vermont;   Virginia;   Washington, DC;   Washington;   West Virginia;   Wisconsin;   Wyoming

Array ( [0] => American Samoa (USA); [1] => Guam (USA); [2] => Puerto Rico (USA); [3] => Virgin Islands (USA); [4] => Northern Mariana Islands (USA); )

USA Territories: American Samoa (USA);   Guam (USA);   Puerto Rico (USA);   Virgin Islands (USA);   Northern Mariana Islands (USA);

USA Compact Free Associations: The Federated States of Micronesia (USA)   Marshall Islands (USA)   Republic of Palau (USA)

Canada: Alberta;   British Columbia;   Manitoba;   New Brunswick;   Newfoundland and Labrador;   Northwest Territories;   Nova Scotia;   Nunavut;   Ontario;   Prince Edward Island;   Quebec;   Saskatchewan;   Yukon;

Israel

International country outside of the USA, Israel and Canada.

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